Bus priority measures are introduced in cities in order to improve travel time, frequency, and reliability, thereby benefiting the passengers and establishing a more attractive and competitive public transport system. Since first being implemented in Chicago in the late 1930s, bus priority measures are now widely applied across the globe, and a plethora of measures regarding priority in terms of time and space are currently in place. The main challenge for planning and implementing bus priority measures is the conflict over space with other societal purposes and road modes, in particular the car. In addition, the introduction of bus priority is often planned and implemented in a context of institutional complexity, which contributes to making such efforts a challenging task. In this article, political leadership, collaboration, alternative funding schemes, guidelines, and action plans are suggested as important instruments to handle these challenges.